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  • Title: Determination of blood ionized calcium in a large segment of the normal adult population.
    Author: Drop LJ, Fuchs C, Stulz PM.
    Journal: Clin Chim Acta; 1978 Nov 01; 89(3):503-10. PubMed ID: 30555.
    Abstract:
    In two different laboratories ionized calcium was determined by use of a calcium selective electrode system of recent design in specimens of whole blood drawn from a total of 100 volunteers. Identical mean values were obtained in each laboratory. A small standard deviation was found supporting the view that [Ca2+] is normally maintained within a narrow range. Ancillary factors in [Ca2+] determination were evaluated, including effects of in-vivo produced changes in pH, and effects of addition of small amounts of heparin to the whole blood sample. A veno-arterial difference in [Ca2+] was insignificant.
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