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  • Title: New cytotoxic constituents in the water-soluble fraction from Momordicae Semen.
    Author: Wang MY, Zhan ZB, Xiong Y, Zhang H, Li XB.
    Journal: Nat Prod Res; 2020 Mar; 34(6):823-829. PubMed ID: 30557059.
    Abstract:
    Two new lignans mubezhisol (1) and mubezhisal (2), together with twenty six known compounds (3-28) were isolated from water-soluble fraction from the semens of Momordica cochinchinensis. In the subsequent action evaluation, four saponins (4, 6, 13, 27), six lignans (1, 2, 16, 17, 22, 23), and one naphthoquinone (24) exhibited the significant cytotoxicity. The results indicated that various saponins and lignans were mainly responsible for the antitumor activities of Momordicae Semen.
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