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  • Title: Peptide-Coated Platinum Nanoparticles with Selective Toxicity against Liver Cancer Cells.
    Author: Shoshan MS, Vonderach T, Hattendorf B, Wennemers H.
    Journal: Angew Chem Int Ed Engl; 2019 Apr 01; 58(15):4901-4905. PubMed ID: 30561882.
    Abstract:
    Peptide-stabilized platinum nanoparticles (PtNPs) were developed that have significantly greater toxicity against hepatic cancer cells (HepG2) than against other cancer cells and non-cancerous liver cells. The peptide H-Lys-Pro-Gly-dLys-NH2 was identified by a combinatorial screening and further optimized to enable the formation of water-soluble, monodisperse PtNPs with average diameters of 2.5 nm that are stable for years. In comparison to cisplatin, the peptide-coated PtNPs are not only more toxic against hepatic cancer cells but have a significantly higher tumor cell selectivity. Cell viability and uptake studies revealed that high cellular uptake and an oxidative environment are key for the selective cytotoxicity of the peptide-coated PtNPs.
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