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  • Title: Chronic Pulmonary Aspergillosis with Pleuroparenchymal Fibroelastosis-like Features.
    Author: Kushima H, Ishii H, Kinoshita Y, Fujita M, Watanabe K.
    Journal: Intern Med; 2019 Apr 15; 58(8):1137-1140. PubMed ID: 30568135.
    Abstract:
    A 64-year-old man who presented with repeated bouts of pneumothorax was admitted to our hospital because of gradually progressive dyspnea and repeated episodes of a fever. The physiological, radiological and pathological findings were consistent with pleuroparenchymal fibroelastosis (PPFE). In addition, the serum-specific precipitating antibody for Aspergillus was positive. After the administration of voriconazole, a marked improvement was observed in the imaging and physiological findings. Given this clinical course, we diagnosed the patient with PPFE secondary to aspergillosis. The present case suggests that a therapeutic approach based on the cause of secondary PPFE may improve the prognosis of PPFE.
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