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  • Title: Asymmetric Synthesis and Cytotoxicity Evaluation of Right-Half Models of Antitumor Renieramycin Marine Natural Products.
    Author: Matsubara T, Yokoya M, Sirimangkalakitti N, Saito N.
    Journal: Mar Drugs; 2018 Dec 20; 17(1):. PubMed ID: 30577460.
    Abstract:
    A general protocol for the asymmetric synthesis of 3-N-arylmethylated right-half model compounds of renieramycins was developed, which enabled structure⁻activity relationship (SAR) study of several 3-N-arylmethyl derivatives. The most active compound (6a) showed significant cytotoxic activity against human prostate cancer DU145 and colorectal cancer HCT116 cell lines (IC50 = 11.9, and 12.5 nM, respectively).
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