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  • Title: Growth and sexual maturation in paediatric patients treated by dialysis and following kidney transplantation.
    Author: Van Diemen-Steenvoorde R, Donckerwolcke RA.
    Journal: Acta Paediatr Scand Suppl; 1988; 343():109-17. PubMed ID: 3057802.
    Abstract:
    Linear growth and sexual maturation were assessed in 48 children during dialysis treatment and in 68 children following renal transplantation. Height at the onset of haemodialysis treatment was more than 2 SD below the mean in 33% of prepubertal children. During dialysis treatment most children showed a progressive deterioration in SD score. The onset of puberty and sexual maturation was delayed but was in accordance with bone age. After transplantation 59% of prepubertal children had a normal height increment. Onset of puberty was recorded at a chronological age of 14.6 +/- 1.9 years in boys and 13.3 +/- 1.9 years in girls. The peak of the pubertal growth spurt was 6.6 +/- 1.6 cm/year in boys and 6.5 +/- 2.9 cm/year in girls. The duration of pubertal development in transplanted children was within normal limits. In transplanted girls menarche was achieved at a mean chronological age of 15.9 years and bone age of 12.9 years. Adult height was achieved at a mean age of 20.3 years in men and 18.7 years in women. Overall, one third of the children attained an adult height more than 2 SD below the mean. These data indicate that poor growth is achieved in most children on dialysis treatment; following transplantation normal growth may be restored. However, poor growth before kidney transplantation and the loss of growth potential during pubertal development have a great influence on adult height.
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