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  • Title: [The phase IV studies with Estracyt in prostatic cancer].
    Author: Ohhori T, Kubo T, Akasaka T, Funyu T, Yagihashi Y, Kudo T, Tsuchida S, Harada T, Sasaki S, Orikasa S.
    Journal: Hinyokika Kiyo; 1988 Aug; 34(8):1493-502. PubMed ID: 3057833.
    Abstract:
    Both anticancer and adverse reactions of Estracyt were investigated by oral administration to 200 patients with prostatic cancer. Two capsules of Estracyt were given twice a day and the administration was principally continued for more than six months. The 200 patients consisted of 68 and 132 patients who were previously untreated and treated, respectively. Thirty seven cases had been treated only with Estracyt and 132 cases also received other treatments. Seventy-five cases were of primary therapy, 71 cases were of maintenance therapy, and 27 cases were of the re-activated stage therapy and 27 cases were of other categories. In conclusion, among the 190 cases for which the due judgement of the effect was possible, Estracyt was markedly effective in 40 cases (21.1%), effective in 43 cases (22.6%), slightly effective in 38 cases (20.0%) and ineffective in 69 cases (36.3%). Adverse reactions were observed in 67 cases (33.5%), among which the administration was discontinued in 18 cases.
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