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  • Title: Return of symptoms after discontinuation of clomipramine in patients with obsessive-compulsive disorder.
    Author: Pato MT, Zohar-Kadouch R, Zohar J, Murphy DL.
    Journal: Am J Psychiatry; 1988 Dec; 145(12):1521-5. PubMed ID: 3057923.
    Abstract:
    To evaluate the need for maintenance drug therapy in patients with obsessive-compulsive disorder, the authors assessed 21 patients with obsessive-compulsive disorder who manifested sustained improvement during 5 to 27 months of clomipramine treatment and who agreed to participate in a double-blind discontinuation study. Of 18 patients who completed the study, 16 had substantial recurrence of obsessive-compulsive symptoms by the end of the 7-week placebo period. In addition, 11 had a significant increase in depressive symptoms. Treatment duration before discontinuation of clomipramine was not related to the frequency or severity of obsessive-compulsive or depressive symptom appearance. These findings suggest that prolonged drug treatment may be warranted for obsessive-compulsive disorder.
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