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  • Title: [Morphofunctional and cytologic characteristics of the endocervix with the use of oral contraceptives].
    Author: Shakhlamova MN.
    Journal: Akush Ginekol (Mosk); 1988 Aug; (8):50-4. PubMed ID: 3057930.
    Abstract:
    Morphofunctional and ultrastructural characteristics of endocervical mucosa were examined for 66 women in their reproductive age prior to and during the use of triphasic oral contraceptives. This type of contraception represents a highly effective method of preventing pregnancy and does not appear to have any negative impact on liver function and the hemostatic system. After 6-12 months' usage, it was discovered that ectopic frequency increased and a that a changed colposcopic appearance of the vaginal section of the cervix uteri occurred, similar to its condition during pregnancy. In the study 15 (23%) of the women noticed large amounts of mucous leukorrhea. The ingestion of triphasic oral contraceptives was accompanied by an increased frequency of planocellular metaplasia and reserve-cell hyperplasia. The development of various types of endocervical hyperplasia may also occur, however with much less frequency (14%). Clinical and histochemical findings were underpinned in more detail by the ultrastructure of different cells in the mucous canal of the cervix uteri. It is possible that the secretory and goblet-like cells that were discovered are related to 1 type of secreted cells passing through various secretory stages. The ultrastructure of the cells in the hyperplastic areas is characterized by an activated functioning of all organellae and, correspondingly, by a hypersecretion of mucous. Moreover, dystrophic cells may develop whose ultrastructure demonstrate the impairment of their proper functioning.
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