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  • Title: Potent α-glucosidase inhibitory activity of compounds isolated from the leaf extracts of Uvaria hamiltonii.
    Author: Meesakul P, Pyne SG, Laphookhieo S.
    Journal: Nat Prod Res; 2020 Sep; 34(17):2495-2499. PubMed ID: 30580591.
    Abstract:
    The phytochemical investigation of the leaf extracts of Uvaria hamiltonii (Annonaceae) led to the isolation and identification of ten compounds including a new seco-cyclohexene (1) together with nine known compounds (2-10). Their structures were elucidated by intensive analysis by spectroscopic methods and comparisons of their spectroscopic data with those of compounds reported in the literature. Compounds 2, 8, and 9 showed potent α-glucosidase inhibitory activity with the IC50 values ranging from 2.6-7.1 µM.
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