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  • Title: MORBIDITY OF THE CIRCULATORY SYSTEM DISEASES OF RESIDENTS FROM RADIOACTIVELY CONTAMINATED AREAS. ANALYSIS OF THE EFFECT OF CHRONIC LOW/DOSE IONIZING RADIATION.
    Author: Buzunov VO, Prykaschykova KY, Yaroshenko ZS, Kostiuk GV, Gubina IG.
    Journal: Probl Radiac Med Radiobiol; 2018 Dec; 23():107-119. PubMed ID: 30582840.
    Abstract:
    OBJECTIVE: to study post-accident levels of illnesses system diseases of residents from radioactively contaminatedareas aged 0-60 years on the date of the Chornobyl accident, and to analyze the effect of chronic low-dose ionizingradiation. MATERIALS AND METHODS: Epidemiological research and analysis of morbidity of circulatory system diseases of resi-dents of radioactively contaminated areas (RCA) has been carried out. The individuals who were studied includedRCA residents aged 0-60 (98, 902 persons) on the date of the Chornobyl accident. The data of the victims' annualmedical examinations during 1988-2016 were received from the State Register of Ukraine (SRU). Detection of thepossible dependence of the development of circulatory system diseases on the effects of ionizing radiation was car-ried out in the range of individual total effective doses ranging from 13-40 mSv and more as accumulated over26 years after the Chornobyl accident. The control group consisted of individuals with a radiation dose of <13 mSv.The statistical analysis of data was performed using the Microsoft Office Excel 2013 software packages. RESULTS: For the entire period of the study, 20,552 cases of circulatory system diseases were detected for the firsttime (ID at 103 person-years is 15.66 ± 0.11), incl. men, respectively, 7,211 cases (12.32 ± 0.14), women - 13,341cases (18.35 ± 0.16). It has been determined that among the circulatory system diseases of RZT residents there isthe most express display of ischemic heart disease, a disease characterized by high blood pressure, including otherheart diseases. The dependence of the levels of morbidity on the diseases of the circulatory system on the sex ofvictims was established. A connection has been established between the development of certain circulatory systemdiseases and the amounts of individual total effective doses of ionizing radiation accumulated over the period of1986-2012. Individual total effective doses of ionizing radiation in men and women in the range of doses of13-40 mSv or more. CONCLUSIONS: On the basis of cohort epidemiological studies, there was studied the dynamics of levels of circulatory system diseases among the RCT residents aged 0-60 years on the date of the Chornobyl accident during the observation period of 1988-2016. The overstated levels of cardiovascular and cerebrovascular diseases were established in the first twelve post-accident years, especially in the first six years. The highest morbidity rates for circulatory system diseases were identified in women over men. The development of certain circulatory system diseases, both in men and women, in a certain period is associated with the amount of dose of ionizing radiation from radionuclides 134Сs, 137Сs. Meta: vyznachennia pisliaavariĭnykh rivniv zakhvoriuvanosti na khvoroby systemy krovoobigu u meshkantsiv radioak-tyvno zabrudnenykh terytoriĭ vikom do 60 rokiv na datu avariï na ChAES, analiz vplyvu khronichnogo ionizuiuchogooprominennia v malykh dozakh.Materialy i metody doslidzhen'. Provedeno epidemiologichne doslidzhennia ta analiz zakhvoriuvanosti na khvoro-by systemy krovoobigu meshkantsiv radioaktyvno zabrudnenykh terytoriĭ (RZT). Kogortu doslidzhuvanykh sklalymeshkantsi RZT u vitsi do 60 rokiv (98 902 osoby) na datu avariï na ChAES. Dani shchorichnykh dyspanseryzatsiĭ postrazh-dalykh za 1988–2016 rr. otrymani z Derzhavnogo reiestru Ukraïny (DRU). Vyiavlennia mozhlyvoï zalezhnosti rozvyt-ku khvorob systemy krovoobigu vid vplyvu ionizuiuchogo oprominennia provodylosia v diapazoni indyvidual'nykh su-marnykh efektyvnykh doz vid 13 do 40 mZv i bil'she, nakopychenykh za 26 rokiv pislia avariï na ChAES. Kontrol'nu gru-pu skladaly osoby z dozoiu oprominennia menshe 13 mZv. Statystychnyĭ analiz danykh vykonanyĭ z vykorystanniamprogramnykh paketiv «Microsoft Office Excel – 2013».Rezul'taty. Za ves' period doslidzhennia vpershe vyiavleno 20 552 vypadky zakhvoriuvan' systemy krovoobigu (IDna 103 liud.-rokiv stanovyt' 15,66 -#177; 0,11), u tomu chysli u cholovikiv – 7 211 vypadkiv (12,32 -#177; 0,14), u zhinok –13 341 (18,35 -#177; 0,16). Vyznacheno, shcho sered khvorob systemy krovoobigu u meshkantsiv RZT naĭbil'she vypadkiv zakh-voriuvanosti na ishemichnu khvorobu sertsia, khvoroby, shcho kharakteryzuiut'sia pidvyshchenym krov’ianym tyskom ta inshikhvoroby sertsia. Vstanovleno zv’iazok rozvytku okremykh zakhvoriuvan' systemy krovoobigu z velychynamy nakopy-chenykh za 1986–2012 rr. indyvidual'nykh sumarnykh efektyvnykh doz ionizuiuchogo oprominennia u cholovikiv i zhinoku diapazoni doz vid 13 do 40 mZv i bil'she.Vysnovky. Na osnovi kogortnykh epidemiologichnykh doslidzhen' vyvchena dynamika rivniv zakhvoriuvanosti na khvo-roby systemy krovoobigu u meshkantsiv RZT vikom 0–60 rokiv na datu avariï na ChAES za period sposterezhenniavprodovzh 1988–2016 rr. Zavyshcheni rivni sertsevo-sudynnykh i tserebrovaskuliarnykh khvorob vstanovleni v pershidvanadtsiat' pisliaavariĭnykh rokiv, osoblyvo v pershi shist' rokiv. Vyshchi pokaznyky zakhvoriuvanosti na khvorobysystemy krovoobigu vyznacheno u zhinok, nizh u cholovikiv. Rozvytok okremykh zakhvoriuvan' systemy krovoobigu iaku cholovikiv, tak i u zhinok u pevnyĭ period pov’iazanyĭ z velychynoiu nakopychenoï za dovgostrokovyĭ period dozyionizuiuchogo oprominennia vid radionuklidiv 134Ss, 137Ss.
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