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Title: MORPHOLOGICAL AND FUNCTIONAL MYOCARDIAL ABNORMALITIES IN THE CHORNOBYL NPP ACCIDENT CLEAN-UP WORKERS OF «IODINE» PERIOD HAVING GOT TYPE 2 DIABETES MELLITUS.
Author: Dombrovska NS, Nastina OM, Voloshko VI, Pleskach OY.
Journal: Probl Radiac Med Radiobiol; 2018 Dec; 23():302-330. PubMed ID: 30582854.
Abstract:
OBJECTIVE: Evaluation of morphological and functional myocardial abnormalities in the Chornobyl NPP (ChNPP)accident clean-up workers (ACUW) of the «iodine» period exposed to ionizing radiation at a young age and havinggot the type 2 diabetes mellitus (T2DM). MATERIALS AND METHODS: The ChNPP ACUW of «iodine» period (n=111) exposed to ionizing radiation (IR) at a young age(18-35 years) were involved in the study. Subjects having got the T2DM were included in study Group I (n = 66), per-sons with normal glucose challenge test were selected as a comparison Group II (n = 45). External radiation doses (ERD)ranged from 10 to 860 mSv. The Group III (clinical control) included persons having got the T2DM with no radiationexposure in a history (n=20). Group IV was the normative one. There was no statistical difference between the groups inage, sociodemographic characteristics and level of education. Echocardiography and cardiac Doppler sonography wereperformed in one- and two-dimensional regimens according to the recommendations of the European Association ofEchocardiography. Total adiponectin and proinflammatory cytokine (TNF-α and IL-6) concentrations were assayed by theimmunoenzyme method. Statistical processing of data was carried out using the Microsoft® Exel 2002 software. RESULTS: Myocardial remodeling in the ChNPP ACUW of a «iodine» period having the T2DM occurred through a sig-nificant increase of its linear parameters. Volumetric parameters (EDV, ESV and their indexes) were within maximumpermissible limits significantly exceeding however the values in the Group IV. There was aт increase in myocardialmass of the left ventricle and its indices with the formation of structural-geometric abnormalities, mainly in theform of concentric hypertrophy with a decrease in the myocardial contractile capacity. There was no differences ofthe vast majority of key morphometric parameters of myocardium in the dose subgroups, while in persons with ERD> 500 mSv the incidence of serious left ventricular hypertrophy (LVMMI > 149 g/m2) significantly exceeded thisvalue in individuals with lower ERD. At a maximum ERD the more intense fibroplastic processes were observed inmyocardium [a significant increase in the interstitial collagen volumetric fraction (ICVF)] as compared to the caseswith ERD up to 50 mSv. Intensification of myocardial fibroblastic processes occurred in the comparizin group andgroup off clinical control. In combination with concentric myocardial hypertrophy this may lead to an increased riskof cardiovascular complications. Strong negative correlation was revealed between the parameters of left ventricu-lar structure in diastole and adiponectin level in the ChNPP ACUW of a «iodine» period with diagnosed T2DM, high-lighting its cardioprotective effect. At the same time, the content of FNP-α and IL-6 proinflammatory cytokines hada positive correlation with the main parameters of abnormal myocardial remodeling, indicating the possibility oftheir role in unfavorable cardiovascular modifications. CONCLUSIONS: The decreased adiponectin level and elevated levels of TNF-α and IL-6 in the ChNPP ACUW of a«iodine» period having got the T2DM are the meaningful factors in progression of LV geometric remodeling. Togetherwith fibroplastic processes (a significant increase in ICVF) this may be a basis for the development of myocardialremodeling processes, namely a concentric hypertrophy, which is a prerequisite for the development of complica-tions in cardiovascular system. Meta: vyvchyty pokaznyky strukturno-funktsional'nykh zmin miokarda v uchasnykiv likvidatsiï naslidkiv avariï (UL-NA) na ChAES ĭodnogo periodu, iaki buly opromineni v molodomu vitsi ta zakhvorily na tsukrovyĭ diabet 2 typu.Materialy ta metody. Obstezheno 111 ULNA na ChAES ĭodnogo periodu, oprominenykh u molodomu vitsi (18–35rokiv), iaki buly rozpodileni na dvi grupy: grupa I (osnovna) – 66 osib, iaki khvoriiut' na TsD 2 typu; grupa II(porivniannia) – 45 osib za naiavnosti nezminenogo gliukozotolerantnogo testu. Dozy zovnishn'ogo oprominenniastanovyly 10,0–860,0 mZv. Grupa III (nozologichnogo kontroliu) – 20 osib, iaki strazhdaiut' na TsD 2 typu, ale nezaznaly diï ionizuiuchogo vyprominiuvannia (IV); IV – normatyvna grupa. Za vikom, sotsiodemografichnymy pokazny-kamy ta rivnem osvity grupy obstezhuvanykh statystychno ne vidriznialys'. Ekhokardiografiiu i dopplerekhokardiog-rafiiu provodyly v odno- ta dvomirnomu rezhymakh zgidno z rekomendatsiiamy European Association ofEchocardiography. Kontsentratsiiu zagal'nogo adyponektynu i prozapal'nykh tsytokiniv (FNP-α ta IL-6) vyznachalyimunofermentnym metodom. Statystychnu obrobku otrymanykh danykh provedeno za dopomogoiu programnogo zabez-pechennia Misrosoft® Ekhsel 2002.Rezul'taty. V ULNA na ChAES ĭodnogo periodu z TsD 2 typu protsesy remodeliuvannia miokarda vidbuvalysia za ra-khunok dostovirnogo zbil'shennia liniĭnykh pokaznykiv. Ob’iemni pokaznyky (KDO, KSO ta ïkh indeksy) znakhodylysia vmezhakh granychno dopustymogo rivnia, prote dostovirno perevyshchuvaly ïkh znachennia v osib normatyvnoï grupy. Ma-lo mistse zbil'shennia masy miokarda livogo shlunochka ta ĭogo indeksiv z formuvanniam strukturno-geometrychnykhzmin, perevazhno, u vygliadi kontsentrychnoï gipertrofiï zi zmenshenniam skorotlyvoï zdatnosti miokarda. Perevazh-na bil'shist' osnovnykh morfometrychnykh pokaznykiv miokarda ne mala vidminnosteĭ v dozovykh pidgrupakh, v toĭzhe chas v osib z DZO ponad 500 mZv chastota znachnoï gipertrofiï livogo shlunochka (IMMLSh ponad 149 g/m2) dos-tovirno perevyshchuvala tseĭ pokaznyk v osib z menshymy dozamy zovnishn'ogo oprominennia. Pry maksymal'nykhznachenniakh DZO vidmichalysia bil'sh intensyvni fibroplastychni protsesy v miokardi [dostovirne zbil'shennia pokaz-nyka ob’iemnoï fraktsiï interstytsial'nogo kolagenu (OFIK)] porivniano z osobamy z DZO do 50 mZv. Posylenniafibroplastychnykh protsesiv u miokardi malo mistse i v patsiientiv grup porivniannia ta nozologichnogo kontroliu. V po-iednanni z kontsentrychnoiu gipertrofiieiu miokarda tse mozhe pidvyshchuvaty ryzyk rozvytku uskladnen' z boku ser-tsevo-sudynnoï systemy. Vyznacheno negatyvnyĭ koreliatsiĭnyĭ zv’iazok syl'nogo stupenia mizh pokaznykamy struk-tury livogo shlunochka v diastolu i adyponektynom v ULNA ĭodnogo periodu, iaki khvoriiut' na TsD 2 typu, shchosvidchyt' pro ĭogo kardioprotektyvnu diiu. Vodnochas, prozapal'ni tsytokiny FNP-α i IL-6 maly pozytyvnyĭ ko-reliatsiĭnyĭ zv’iazok z osnovnymy pokaznykamy patologichnogo remodeliuvannia, shcho vkazuie na mozhlyvist' ïkhn'ogovplyvu na formuvannia negatyvnykh sertsevo-sudynnykh zmin.Vysnovky. Znyzhenyĭ riven' adyponektynu i pidvyshchenyĭ FNP-α ta IL-6 v ULNA na ChAES ĭodnogo periodu, iakikhvoriiut' na TsD 2 typu, vidigraiut' vazhlyvu rol' iak faktory progresuvannia geometrychnogo remodeliuvannia LSh.U sukupnosti z fibroplastychnymy protsesamy (dostovirne zbil'shennia OFIK) tse mozhe sklasty pidґruntia dlia roz-vytku protsesiv remodeliuvannia miokarda, a same kontsentrychnoï gipertrofiï, shcho ie peredumovoiu rozvytku usklad-nen' u sertsevo-sudynniĭ systemi.

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