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  • Title: CLINICAL, HEMATOLOGICAL CHARACTERIZATION AND POLYMORPHISM OF ABO AND Rh BLOOD GROUP SYSTEMS IN PLASMA CELL MYELOMA PATIENTS.
    Author: Liubarets TF, Minchenko ZM, Dmytrenko OO, Khomenko VI, Reznikova LS, Shlyahtichenko TY, Tovstogan AO, Silayev YO.
    Journal: Probl Radiac Med Radiobiol; 2018 Dec; 23():410-422. PubMed ID: 30582859.
    Abstract:
    UNLABELLED: Objective to study the peculiarities of clinical characteristics and polymorphism of ABO and Rh blood group systemsin relation to the natural history of plasma cell myeloma in the ChNPP accident survivors. MATERIALS AND METHODS: Peculiarities of the disease natural history were reviewed in the 111 plasma cell myeloma(PCM) patients receiving medical management at the Department of Radiation Oncohematology of the NRCRM dur-ing 2010-2017. Principal clinical and laboratory characteristics of PCM, namely the values/levels of LDH, β2-mic-roglobulin, albumin, serum calcium, urea, creatinine and hemoglobin were assessed, taking into account the gender,radiation history (ChNPP accident clean-up workers, evacuees from areas of obligatory resettlement, inhabitants ofcontaminated territories, and the comparison group) and the PCM stage codenamed by Durie-Salmon et al. (1975)and the ISS (1985) classifications. Distribution of polymorphic variants on ABO and Rh blood systems was studiedin the 106 PCM patients. RESULTS: It was found that the level of β2-micro-globulin and calcium was increased significantly in male (p = 0.02and p = 0.04, respectively), whereas serum urea content was elevated in female (p = 0.04) PCM patients featuring acompromised radiation anamnesis in comparison to non-irradiated patients. Some probable differences were foundfor urea level (F = 3.58, p = 0.05) and serum albumin (F = 4.00, p = 0.05) in the examined group of PCM patients.Probable (p < 0.05) incidence increase of the B phenotype was established as a predictor of complicated natural his-tory of PCM with abnormal genetic equilibrium resulted from the increased incidence of IB allele in chronic renal fail-ure (CRF) patients. Significant (p < 0.05) prolongation of the remission period upon a standard PCT application wasfound in PCM patients being the A phenotype carriers having a preserved gene and phenotypic equilibrium comparedwith carriers of O and B phenotypes. CONCLUSIONS: Clinical and hematological parameters are different in PCM patients survived after the ChNPP accidentand those with favorable radiation history. Distribution of polymorphic variants of ABO antigenic structures inpatients with complicated natural history of the disease is also different, that can be a background for predictingthe effectiveness of treatment. Further research is required in this field. Meta: vyvchyty osoblyvosti klinichnykh kharakterystyk ta polimorfizm system grup krovi AVO, Rh shchodo perebiguplazmoklitynnoï miielomy u patsiientiv, postrazhdalykh vnaslidok avariï na ChAES.Materialy i metody. Proanalizovano osoblyvosti perebigu zakhvoriuvannia u 111 patsiientiv z plazmoklitynnoiumiielomoiu (PKM), iaki znakhodylys' na obstezhenni ta likuvanni u viddilenni radiatsiĭnoï onkogematologiï NNTsRMprotiagom 2010–2017 rr. Otsineno osnovni kliniko-laboratorni kharakterystyky PKM (riven' laktatdegidrogena-zy, β2-mikroglobulinu, al'buminu, kal'tsiiu syrovatky krovi, sechovyny, kreatyninu ta rivnia gemoglobinu) z urakhu-vanniam stati, radiatsiĭnogo anamnezu (uchasnyky likvidatsiï naslidkiv avariï na ChAES, evakuĭovani z zon bezumov-nogo vidselennia, zhyteli kontaminovanykh terytoriĭ ta grupa porivniannia), stadiï PKM za klasyfikatsiieiu Durie-Salmon et al. (1975) ta ISS (1985). Provedeno doslidzhennia rozpodilu polimorfnykh variantiv za systemamy kroviAVO ta Rh u 106 patsiientiv z PKM.Rezul'taty. Vstanovleno, shcho u khvorykh na PKM z obtiazhenym radiatsiĭnym anamnezom porivniano z neopromineny-my patsiientamy virogidno zrostaly: u cholovikiv – riven' β2-mikro-globulinu (r = 0,02) ta kal'tsiiu (r = 0,04),u zhinok - riven' sechovyny syrovatky krovi (r = 0,04). Pidtverdzheno, shcho dlia obstezhenoï grupy patsiientiv zPKM virogidni vidminnosti vstanovleni shchodo rivnia sechovyny (F = 3,58; r = 0,05) ta al'buminu syrovatky krovi(F = 4,00; r = 0,05). Vstanovleno virogidne (r -#060; 0,05) pidvyshchennia chastoty zustrichal'nosti fenotypu V iak predyk-tora uskladnenogo perebigu PKM z porushenniam gennoï rivnovagy vnaslidok zrostannia chastoty aleliu IB upatsiientiv z khronichnoiu nyrkovoiu nedostatnistiu. U khvorykh na PKM pry nosiĭstvi fenotypu A na tli zberezhenniagennoï i fenotypovoï rivnovagy vstanovleno suttieve (r -#060; 0,05) podovzhennia periodu remisiï pry provedenni stan-dartnoï polikhimioterapiï u porivnianni z nosiiamy fenotypiv O i V.Vysnovky. Vyiavleni vidminnosti kliniko-gematologichnykh pokaznykiv u patsiientiv z PKM, postrazhdalykh vnaslidokavariï na ChAES, i osib bez obtiazhenogo radiatsiĭnogo anamnezu ta rozpodilu polimorfnykh variantiv antygennykhstruktur AVO u khvorykh z uskladnenym perebigom zakhvoriuvannia, shcho mozhe sklasty pidґruntia dlia prognozuvanniaefektyvnosti likuvannia i potrebuie podal'shykh doslidzhen' v danomu napriamku.
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