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Title: THE EFFECT OF APPLICATION OF ANTIOXIDANT THERAPY IN THE TREATMENT OF NON-ALKOHOLIC STEATOHEPATATIS IN CHORNOBYL NPP ACCIDENT SUFFERERS IN THE REMOTE PERIOD AFTER IRRADIATION.
Author: Sarkisova EA, Chumak AA, Ovsyannikova LM, Alekhina LM, Nosach OV, Gasanova EO, Shyiko TO.
Journal: Probl Radiac Med Radiobiol; 2018 Dec; 23():452-461. PubMed ID: 30582862.
Abstract:
OBJECTIVE: to determine the effectiveness of combined treatment with hepatoprotectors and antioxidant a complexpreparation of vitamins A and E (I) in patients with non-alcoholic steatohepatitis (NASH) who suffered from theChornobyl NPP accident based on the results of evaluation of metabolic changes. MATERIALS AND METHODS: The state of the hepatobiliary system of 72 patients with NASH suffered as a result of theChornobyl accident was studied based on the results of the biochemical analysis of blood, indicators characterizingthe processes of oxidative modification of macromolecules and the state of the antioxidant system (AOS), as well asstructural changes in the liver according to ultrasound investigations in the course of the examination before andafter treatment. RESULTS: The treatment of NASH with hepatoprotectors and antioxidant I in the sufferers of the Chornobyl accidentincreased the level of antioxidant defense products (catalase and superoxide dismutase) with the normalization ofthe integral index of the AOS, and a significant decrease in the number of patients with reduced AOS status (from42.6% to 24, 2%, p <0.05), positive dynamics of biochemical parameters of blood with decreasing frequency ofdetection of cholestasis syndrome, hypercholesterolemia and hyperglycemia were established as well as the positivedynamics of structural changes in the liver according to ultrasound data. CONCLUSION: Combined therapy of NASH with hepatoprotectors and antioxidant I in patients who suffered from theChornobyl NPP accident contributes to the restoration of the prooxidant-antioxidant balance, decreases cholestasis,hypercholesterolemia and hyperglycemia, and promotes positive dynamics of structural changes in the liver. Meta: vyznachyty za rezul'tatamy otsinky metabolichnykh zmin efektyvnist' kombinovanogo likuvannia gepatopro-tektoramy ta antyoksydantom kompleksnym preparatom vitaminiv A ta E (I) patsiientiv z nealkogol'nym steatoge-patytom (NASG), iaki postrazhdaly vnaslidok avariï na ChAES.Materialy i metody. Doslidzheno stan gepatobiliarnoï systemy 72 khvorykh na NASG, iaki postrazhdaly vnaslidokavariï na ChAES, za rezul'tatamy biokhimichnogo analizu krovi, pokaznykiv, shcho kharakteryzuiut' protsesy okysliu-val'noï modyfikatsiï makromolekul i stan antyoksydantnoï systemy (AOS), a takozh strukturnykh zmin pechinky zadanymy ul'trazvukovogo doslidzhennia v protsesi obstezhennia do ta pislia provedenogo likuvannia.Rezul'taty. Pry zastosuvanni antyoksydantnoï terapiï I razom z gepatoprotektoramy v likuvanni NASG u post-razhdalykh vnaslidok avariï na ChAES vstanovleno pidvyshchennia rivnia produktiv antyoksydantnogo zakhystu (kata-lazy ta superoksyddysmutazy) z normalizatsiieiu integral'nogo pokaznyka stanu AOS, zmenshennia kil'kostipatsiientiv z pidvyshchenymy rivniamy POL i dostovirne zmenshennia kil'kosti khvorykh zi znyzhenym stanom AOS(z 42,6 % do 24,2 %, r -#060; 0,05), pozytyvna dynamika biokhimichnykh pokaznykiv krovi zi zmenshenniam chastoty vyiav-lennia syndromu kholestazu, giperkholesterynemiï ta giperglikemiï, pozytyvna dynamika strukturnykh zmin pechinkyza danymy ul'trazvukovogo doslidzhennia.Vysnovok. Kombinovana terapiia NASG gepatoprotektoramy ta antyoksydantom I u patsiientiv, iaki postrazhdalyvnaslidok avariï na ChAES, spryiaie vidnovlenniu prooksydantno-antyoksydantnoï rivnovagy, zmenshenniu kholesta-zu, giperkholesterynemiï i giperglikemiï ta pozytyvniĭ dynamitsi strukturnykh zmin pechinky.

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