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  • Title: Influence of insulin on mitotic rate in cultivated mammalian cells.
    Author: Komolov IS, Fedotov VP.
    Journal: Endocrinol Exp; 1978 Mar; 12(1):43-8. PubMed ID: 305845.
    Abstract:
    The influence of insulin (100 mU ml-1) on the mitotic rate in a tissue culture of muscle fibroblasts L was studied. The metod of temporary inhibition of cell transformation from G1 to S period with the aid of maintaining cells in serum free medium was used. Moreover, the number of mitoses in a stage of metaphasis after the addition of colchicine was counted and autoradiography was used. Insulin showed two independent effects on mitotic cycle: first it initiated the synthesis of DNA and increased the rate of a transformation of cells from a period G1 into period S; second--it increased the rate of processes at the final stages of mitotic cycle and increased the number of cells entering this cycle.
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