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  • Title: [Establishment of experimental method for bone-conducted vibration elicited vestibular-evoked myogenic potentials in healthy guinea pigs].
    Author: Chen ZC, Hu J, Zhang YZ, Wei XY, Yang YZ, Gao Y, Xu Y, Cheng Y, Chen FY, Xu M, Zhang Q.
    Journal: Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi; 2018 Dec 07; 53(12):939-943. PubMed ID: 30585007.
    Abstract:
    Objective: To estabilsh animal methods of bone-conducted vibration elicited cervical vestibular-evoked myogenic potentials (BCV-cVEMP) and ocular vestibular-evoked myogenic potentials (BCV-oVEMP) in healthy guinea pigs. Methods: Eleven healthy (250-350 g) and awake guinea pigs were selected and undertake conventional BCV-cVEMP and BCV-oVEMP examination in prone position. Parameters of waveforms were cauculated. Results: The BCV-cVEMP and BCV-oVEMP both could be elicited in 100% (22/22) in guinea pigs respectively, threshold was (85.5±10.8)dB SPL and (90.7±10.6)dB SPL for cVEMP and oVEMP; n1 latency was (4.5±1.3)ms and (4.3±1.5)ms for cVEMP and oVEMP; p1 latency was (5.8±1.4)ms and (5.6±1.7)ms respectively; n1-p1 interwave latency was (1.2±0.4)ms for cVEMP and (1.4±0.6)ms for oVEMP, amplitude was (21.5±17.3)μV and (24.0±16.3)μV respectively. Conclusion: Both BCV-cVEMP and BCV-oVEMP can be successfully elicited in healthy guinea pigs. 目的： 通过骨导振动刺激(bone－conducted vibration，BCV)诱发健康豚鼠颈肌前庭诱发肌源性电位(cervical vestibular－evoked myogenic potentials，cVEMP)和眼肌前庭诱发肌源性电位(ocular vestibular－evoked myogenic potentials，oVEMP)，从而建立稳定的豚鼠BCV－cVEMP/BCV－oVEMP实验方法并获取正常值参数。 方法： 选取11只(22耳)健康豚鼠，在动物清醒状态下通过特制的固定架，保持其俯卧抬头位后行BCV－cVEMP、BCV－oVEMP测试，分析记录BCV－cVEMP和BCV－oVEMP的波形特点和参数。 结果： 11只健康豚鼠中BCV－cVEMP和BCV－oVEMP的引出率均为100%(22/22)。BCV－cVEMP的阈值为(85.5±10.8)dBSPL，n1潜伏期为(4.5±1.3)ms，p1潜伏期为(5.8±1.4)ms，n1－p1波间期为(1.2±0.4)ms，振幅为(21.5±17.3)μV。BCV－oVEMP的阈值为(90.7±10.6)dBSPL，n1潜伏期为(4.3±1.5)ms，p1潜伏期为(5.6±1.7)ms，n1－p1波间期为(1.4±0.6)ms，振幅为(24.0±16.3)μV。 结论： 本实验在健康豚鼠身上成功诱发出稳定的BCV－cVEMP和BCV－oVEMP波形，并获取阈值、潜伏期和振幅等参数。.
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