These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: [Clinicopathologic and survival analysis of synchronous primary endometrial and ovarian cancer].
    Author: Wang Y, Yu M, Yang JX, Cao DY, Zhang Y, Shen K, You Y.
    Journal: Zhonghua Fu Chan Ke Za Zhi; 2018 Dec 25; 53(12):816-822. PubMed ID: 30585019.
    Abstract:
    Objective: To demonstrate the clinicopathological characteristics and determine the prognostic factors for women with synchronous primary endometrial and ovarian cancer (SEOC) . Methods: A retrospective analysis of 63 pathologically proven cases of SEOC diagnosed in Peking Union Medical College Hospital from January 2000 to May 2018 was carried out. Results: (1) Clinical features: mean age at diagnosis was (48.3±10.0) years, and the mean body mass index (BMI) was (23.4±3.7) kg/m(2). The most common presenting symptom was abnormal uterine bleeding with a ratio of 73% (46/63). Forty-three patients (68%, 43/63) were premenopausal, and 30% (19/63) were nulliparous. (2) Pathological features: for the endometrial cancer, 90% patients were diagnosed at stage Ⅰ, and 81% were low grade tumors (G(1)-G(2)). The histological type of endometrial cancer was mainly endometrioid carcinoma (86%) and majority (81%) of patients were proved without or with superficial myometrial invasion. For the ovarian cancer, 70% patients were diagnosed at stage Ⅰ and 65% were low grade tumors (G(1)-G(2)). Sixty-two percent of ovarian cancers were endometrioid carcinoma and 68% of patients had unilateral involvement of the ovaries. (3) Treatment and prognosis: all patients underwent surgery, of which 56 (89%) underwent staging surgery including retroperitoneal lymphadenectomy, and 57 (90%) received postoperative adjuvant therapy. The median follow-up time was 48.0 months (range, 2-176 months) , and 13% of the patients experienced tumor recurrence during the follow-up period. The median time to recurrence was 38.5 months, and 6 patients (10%) died of tumor recurrence. The 5-year progression-free survival (PFS) and 5-year overall survival (OS) for all patients were 69% and 80%, respectively. (4) Prognostic factors: univariate analysis showed that the presence of lymphovascular space invasion (LVSI) , non-endometrioid histology of ovarian cancer and stage of ovarian cancer above stage Ⅰ were associated with significantly worse PFS (P<0.05). LVSI, high grade of endometrial cancer, and above stage Ⅰ of ovarian cancer were associated with significantly worse OS (P<0.05). On multivariate analysis, LVSI, non-endometrioid type ovarian cancer and stage of ovarian cancer above stage Ⅰwere associated with significantly worse PFS (P<0.05). In addition, LVSI and stage of ovarian cancer above stage Ⅰ were also associated with significantly worse OS (P<0.05) . Conclusions: Women with SEOC are young, premenopausal and have a favorable overall prognosis. Presence of LVSI, non-endometrioid type ovarian cancer and stage of ovarian cancer above stage Ⅰ are independent prognostic factors for PFS, and stage of ovarian cancer above stage Ⅰare independent prognostic factors for OS. 目的： 探讨子宫内膜和卵巢同期原发性双癌（SEOC）患者的临床病理特征点及预后影响因素。 方法： 回顾性分析2000年1月—2018年5月于中国医学科学院北京协和医院诊治并经病理检查证实的63例SEOC患者的临床病理资料，探讨SEOC的治疗及预后，并对影响SEOC患者预后的相关因素进行分析。 结果： （1）临床特点：63例SEOC患者诊断时的年龄为（48.3±10.0）岁，体质指数（BMI）为（23.4±3.7）kg/m(2)；首诊症状为异常子宫出血者占73%（46/63）；未生育者占30%（19/63），未绝经者占68%（43/63）。（2）病理特点：SEOC中的子宫内膜癌主要为低手术病理分期（Ⅰ期占90%）、低病理分级（G(1)~G(2)占81%），病理类型以子宫内膜样癌为主（占86%），浸润深度以无或浅肌层浸润为主（占81%）；SEOC中的卵巢上皮性癌（卵巢癌）主要为低手术病理分期（Ⅰ期占70%）、低病理分级（G(1)~G(2)占65%），病理类型以子宫内膜样癌为主（占62%），以卵巢单侧受累为主（占68%）。（3）治疗及预后：63例SEOC患者均接受了手术治疗，其中56例（89%）接受了包括腹膜后淋巴清扫在内的分期手术，57例（90%）接受了术后辅助治疗。中位随访时间为48.0个月（2~176个月），随访期间内复发8例（13%），复发的中位时间为38.5个月，死于肿瘤复发者6例（10%）；SEOC患者的5年无进展生存率（PFS）为69%，5年总生存率（OS）为80%。（4）预后影响因素分析：单因素分析显示，淋巴脉管间隙浸润（LVSI）、卵巢癌为非子宫内膜样癌、卵巢癌手术病理分期高于Ⅰ期者的5年PFS更差（P<0.05），LVSI、SEOC中子宫内膜癌为高病理分级、SEOC中卵巢癌的手术病理分期高于Ⅰ期者的5年OS更差（P<0.05）；多因素分析显示，LVSI、SEOC中卵巢癌的病理类型和手术病理分期为影响SEOC患者5年PFS的独立因素（P<0.05），LVSI、SEOC中卵巢癌的手术病理分期是影响SEOC患者5年OS的独立因素（P<0.05）。 结论： SEOC患者通常较为年轻，多为绝经前女性，预后较好。LVSI、卵巢癌为非子宫内膜样癌以及卵巢癌手术病理分期高于Ⅰ期是影响SEOC患者5年PFS的独立因素，而LVSI与卵巢癌手术病理分期高于Ⅰ期是影响SEOC患者5年OS的独立因素。.
    [Abstract] [Full Text] [Related] [New Search]