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Title: Pulse-radiolysis studies of 8-methoxypsoralen. Author: Redpath JL, Ihara J, Patterson LK. Journal: Int J Radiat Biol Relat Stud Phys Chem Med; 1978 Apr; 33(4):309-15. PubMed ID: 305907. Abstract: Both eaq- and .OH have been found to react with 8-methoxypsoralen (8-MOP), giving rate-constants of 1.1 X 10(10) M-1 s-1. Transient spectra of products from the reactions of eaq-, .OH with 8-MOP have been characterized. Rate-constants for the oxidation by 8-MOP of reduced and oxidized DNA bases have also been measured and found to lie in the range 3-6 X 10(9) M-1 s-1. Oxidation of reduced bases occurs by electron transfer with 100 per cent efficiency in all cases. However, for oxidized bases, only approximately 25 per cent of the intermediate yield produced by OH attack undergoes electron transfer; the balance of the oxidized base appears to form adducts with 8-MOP.[Abstract] [Full Text] [Related] [New Search]