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  • Title: The elastase-inhibitor eglin has no effect in an ovine model of endotoxemia.
    Author: Redl H, Schlag G, Vogl C, Schiesser A, Paul E, Thurnher M, Junger W, Traber LD, Traber DL.
    Journal: Biol Chem Hoppe Seyler; 1988 May; 369 Suppl():153-6. PubMed ID: 3060136.
    Abstract:
    Small doses of endotoxin have been shown to induce pulmonary microvascular injury in sheep, possibly by the action of granulocytes. Eglin, a potent inhibitor of neutrophil elastase, was tested in an ovine model of endotoxemia. The experiment was performed in 12 unanesthetized chronically instrumented sheep with a lung lymph preparation. Endotoxin (S. abort. equii) was infused at 24 ng/(kg x h) with application of 20 mg/kg eglin 1 h before endotoxin in the treatment group and followed by 5 mg/(kg x h). No significant improvement due to the treatment was seen for either cardiovascular status (pulmonary and systemic vascular resistance) or permeability changes in the lung (lymph flow and lymph/plasma protein ratio), although sufficient eglin concentrations were achieved in plasma and lymph. The lack of an effect of eglin might be because higher concentrations are needed to block elastase-like activity of ovine granulocytes or because of a minor role for neutrophil elastase in this shock model.
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