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  • Title: Emergence of a Multidrug-Resistant Hypervirulent Klebsiella pneumoniae Sequence Type 23 Strain with a Rare blaCTX-M-24-Harboring Virulence Plasmid.
    Author: Shen D, Ma G, Li C, Jia X, Qin C, Yang T, Wang L, Jiang X, Ding N, Zhang X, Yue L, Yin Z, Zeng L, Zhao Y, Zhou D, Chen F.
    Journal: Antimicrob Agents Chemother; 2019 Mar; 63(3):. PubMed ID: 30602516.
    Abstract:
    Here, we report a multidrug-resistant hypervirulent Klebsiella pneumoniae (MDR-HvKP) strain of sequence type 23 (ST23) with a rare hybrid plasmid harboring virulence genes and blaCTX-M-24, and we analyze the genetic basis for relationship between genotypes and MDR-hypervirulence phenotypes. Further analysis indicates that the hybrid plasmid is formed by IS903D-mediated intermolecular transposition of the blaCTX-M-24 gene into the virulence plasmid. The emergence of MDR-HvKP strains, especially those carrying drug-resistant virulent plasmids, poses unprecedented threats/challenges to public health. This is a dangerous trend and should be closely monitored.
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