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  • Title: A retrospective study of Creutzfeldt-Jakob disease in Italy (1972-1986).
    Author: Masullo C, Pocchiari M, Neri G, Casaccia P, Iavarone A, Ladogana A, Macchi G.
    Journal: Eur J Epidemiol; 1988 Dec; 4(4):482-7. PubMed ID: 3060369.
    Abstract:
    In a retrospective study of Creutzfeldt-Jakob disease (CJD) in Italy from 1972 to 1986, we found 79 cases which fulfilled the diagnostic criteria for CJD. The annual mortality rate was 0.09 cases per million inhabitants. In this series the female to male ratio was 2.59, a value significantly higher than that found in Italian population (1.05). The mean age at death was 62.1 +/- 9.4 years and the mean duration of the disease was 5.3 +/- 3.0 months. No familial cases of CJD were found in our series. Mental deterioration was present in all of our cases, myoclonus in 85% and the other clinical signs were present at a lower rate. Periodic EEG activity was found in 92% of the cases. Two patients had had neurological or ophthalmic surgery and 17% of our cases had undergone general surgery within 5 years prior to the clinical onset of CJD.
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