These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Developmental study of SV40 large T antigen expression in transgenic mice with choroid plexus neoplasia.
    Author: Messing A, Pinkert CA, Palmiter RD, Brinster RL.
    Journal: Oncogene Res; 1988; 3(1):87-97. PubMed ID: 3060799.
    Abstract:
    Expression of SV40 large T antigen was correlated with the development of pathology in three lines of transgenic mice. Immunohistochemical detection of large T revealed positive cells only in subsets of choroid plexus epithelium, thymus and renal tubular epithelium, which was first observed during the first month of post-natal life. Morphologic abnormalities became apparent several weeks later. Only some of the choroid plexus cells which expressed T antigen progressed to form neoplasms, suggesting the need for one or more secondary events to effect transformation. Tumors did not develop in thymus and kidney.
    [Abstract] [Full Text] [Related] [New Search]