These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Effect of progesterone in long-term endometrial cell culture: study of the synthesis of prostaglandins, thromboxane, prostacyclin and prolactin.
    Author: Nemme R, Acker GM, Papiernik E.
    Journal: Eur J Obstet Gynecol Reprod Biol; 1988 Jul; 28(3):221-8. PubMed ID: 3061845.
    Abstract:
    Cultured monolayers of endometrial cells synthesized PGE2, PGF2 alpha, 13,14-dihydro-15-keto-PGF2 alpha (DHKF2 alpha), TXB2 and 6-keto-PGF1 alpha. Synthesis increased with the duration of culture, reaching a maximum at approximately the 20th day for PGF2 alpha and PGE2; PGF2 alpha levels always exceeded those of PGE2. Transformation of PGF2 alpha into DHKF2 alpha was minimal. Maximal levels of TXB2 and 6-keto-PGF1 alpha were noted after 7 and 14 days respectively. After three weeks, traces of DHKF2 alpha, TXB2 and 6-keto-PGF1 alpha were noted, whereas PGF2 alpha levels were marked after 30 days of culture. Addition of progesterone (0.32 ng/ml) reduced PG production, notably for PGF2 alpha, but promoted prolactin synthesis, indicating that this progesterone concentration induced decidualization of endometrial cells during the first days of culture.
    [Abstract] [Full Text] [Related] [New Search]