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  • Title: Alterations in lipid metabolism induced by antihypertensive therapy.
    Author: Amery A, Lijnen P.
    Journal: Drugs; 1988; 36 Suppl 2():1-5. PubMed ID: 3063502.
    Abstract:
    Adverse effects on serum triglycerides and cholesterol fractions have been reported in hypertensive patients treated with diuretics and non-selective beta-blockers. However, the changes induced by cardioselective beta-blockers and those with intrinsic sympathomimetic activity (ISA) or by alpha-blockers have been shown to be more favourable. In addition, evidence suggests that calcium antagonists and angiotensin-converting enzyme (ACE) inhibitors have little effect on serum lipid concentrations in hypertensive patients, although until now only diuretics and beta-blockers without ISA have been shown to reduce morbidity and mortality.
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