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  • Title: Multicentre study of the efficacy and tolerance of acebutolol versus atenolol in the long term treatment of mild arterial hypertension.
    Author: De Backer G.
    Journal: Drugs; 1988; 36 Suppl 2():51-6. PubMed ID: 3063506.
    Abstract:
    The efficacy, tolerance and effect on serum lipids of acebutolol were compared with those of atenolol over a 6-month period in a large group of patients with mild arterial hypertension. Both drugs were equally effective in reducing blood pressure, and tolerance was generally excellent. High density lipoprotein (HDL)-cholesterol concentrations were reduced to a similar extent by both treatments at 2 months and this change was reflected in measurements of the total cholesterol concentrations. However, no significant changes occurred in serum triglyceride levels and at 6 months all serum lipid parameters had returned to baseline values. These observations suggest that cardioselective beta-blockers have no adverse effects on serum lipids at 6 months, after a temporary reduction of HDL-cholesterol at 2 months.
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