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  • Title: [Early postoperative thrombosis of an aortic Saint-Jude prosthesis. Success of fibrinolytic treatment].
    Author: Sadoun D, Komajda M, Drobinski G, Thomas D, Vanetti A, Grosgogeat Y.
    Journal: Ann Cardiol Angeiol (Paris); 1988; 37(7):365-9. PubMed ID: 3064693.
    Abstract:
    We are reporting the case of a 63 year-old woman presenting an early thrombosis of a mechanical aortic Saint-Jude prosthesis, on the 21st post-operative day, following an insufficient anti-coagulant treatment and discovered by the presence of a well tolerated murmur of aortic insufficiency. The treatment consisted in fibrinolysis using urokinase, administered intravenously at a dose of 4,400 IU/kg/hour, for 12 hours. The clinical, ultrasound and radiocinematographic control performed on the 75th day, were normal; the patient, at that time being treated with anti-vitamin K and platelets anti-aggregates. No complication was observed. This case demonstrates the advantages of fibrinolytic treatments in early thrombosis following insertion of a valvular prosthesis.
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