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  • Title: The kinetics of SHV-2 plasmid-mediated beta-lactamase compared to those of the parent enzyme from which it is derived.
    Author: Labia R, Morand A, Tiwari K, Pitton JS, Sirot D, Sirot J, Ben Yaghlane H, Boujenah A.
    Journal: Drugs Exp Clin Res; 1988; 14(5):335-9. PubMed ID: 3065020.
    Abstract:
    Kinetic constants were determined for two closely related plasmid-mediated beta-lactamases: SHV-2 and PIT-2 (also known as SHV-1). These enzymes were synthesized constitutively. They were highly sensitive to the action of the inhibitors clavulanic acid and sulbactam, and they lacked activity against cephamycins and also imipenem. Both enzymes were significantly active against penicillins and first-generation cephalosporins, and the main difference concerned the third-generation cephalosporins: SHV-2 was highly active against these compounds whereas PIT-2 was not.
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