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  • Title: [Mutagenicity of benzene metabolites by fluctuation test].
    Author: Koike N, Haga S, Ubukata N, Sakurai M, Shimizu H, Sato A.
    Journal: Sangyo Igaku; 1988 Nov; 30(6):475-80. PubMed ID: 3065545.
    Abstract:
    Mutagenicity of five benzene metabolites was examined by a fluctuation test modified by Gatehouse. The test was performed by using Salmonella typhimurium TA100 with or without a metabolic activation system. Catechol showed mutagenic activity with and without a metabolic activation system in the fluctuation test. Hydroxyhydroquinone, phenol, hydroquinone and p-benzoquinone were positive only with a metabolic activation system in this test. The Ames' plate method and preincubation method are widely used as a screening test for the mutagenic compounds. However, the fluctuation test is very useful in detecting mutagenic activity of chemicals which are negative in the Ames test though being a mutagen or carcinogen.
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