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  • Title: [Interaction between various alkylxanthines and the proteins of the erythrocyte skeleton].
    Author: Delaunay J, Pothier B, Baklouti F, Morlé L.
    Journal: Pathol Biol (Paris); 1988 Oct; 36(8 Pt 2):1076-80. PubMed ID: 3065699.
    Abstract:
    We searched an interaction between (i) pentoxifylline and/or propentofylline, and (ii) the red cell membrane with special emphasis on the membrane skeleton. It appeared (i) that propentofylline has no permanent binding site on the membrane, (ii) that propentofylline and/or pentoxifylline do not detectably alter spectrin conformation (no change of spectrin dimer self-association or of spectrin limited digestion in the presence of trypsin), and (iii) that these compounds have no effect on membrane protein phosphorylation, particularly the cAMP-dependent and TPA-dependent phosphorylation of protein 4.1.
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