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  • Title: Blockade of a late inhibitory postsynaptic potential in hippocampal CA3 neurons in vitro reveals a late depolarizing potential that is augmented by pentobarbital.
    Author: Thalmann RH.
    Journal: Neurosci Lett; 1988 Dec 19; 95(1-3):155-60. PubMed ID: 3067125.
    Abstract:
    These experiments show that blockade of a late inhibitory postsynaptic potential (IPSP) in rat hippocampus by injection of GTP gamma s into a single monitored neuron, or by injection of pertussis toxin into the hippocampus, exposed a synaptic potential that was depolarizing relative to the early, GABAA mediated IPSP. The reversal potential of this late depolarizing potential (LDP) was 10-12 mV positive to that of the early IPSP. The response was augmented by 40-60 microM pentobarbital, and the augmented response appeared to be sensitive to picrotoxin, an antagonist of GABAA action. The LDP is comparable to a depolarizing GABAA synaptic response that had been previously observed only when synaptic behavior of slices was grossly altered by exposure to pentobarbital or 4-aminopyridine.
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