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Title: Adenine nucleotides as paracrine mediators and intracellular second messengers in immunity and inflammation. Author: Fliegert R, Heeren J, Koch-Nolte F, Nikolaev VO, Lohr C, Meier C, Guse AH. Journal: Biochem Soc Trans; 2019 Feb 28; 47(1):329-337. PubMed ID: 30674608. Abstract: Adenine nucleotides (AdNs) play important roles in immunity and inflammation. Extracellular AdNs, such as adenosine triphosphate (ATP) or nicotinamide adenine dinucleotide (NAD) and their metabolites, act as paracrine messengers by fine-tuning both pro- and anti-inflammatory processes. Moreover, intracellular AdNs derived from ATP or NAD play important roles in many cells of the immune system, including T lymphocytes, macrophages, neutrophils and others. These intracellular AdNs are signaling molecules that transduce incoming signals into meaningful cellular responses, e.g. activation of immune responses against pathogens.[Abstract] [Full Text] [Related] [New Search]