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  • Title: Radical alkylation of isocyanides with amino acid-/peptide-derived Katritzky salts via photoredox catalysis.
    Author: Zhu ZF, Zhang MM, Liu F.
    Journal: Org Biomol Chem; 2019 Feb 06; 17(6):1531-1534. PubMed ID: 30681112.
    Abstract:
    An efficient and mild method was developed for the synthesis of 6-alkylated phenanthridines upon visible light irradiation. Bench-stable and easily handled redox-active Katritzky pyridinium salts derived from abundant amino acids/peptides were used as radical precursors for the alkylation of isocyanobiphenyl species. The reaction displays an excellent functional group tolerance and a potential utility for peptide functionalization, allowing access to desired products in good to excellent yields.
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