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  • Title: Palladium(II)-Catalyzed Enantioselective Aminotrifluoromethoxylation of Unactivated Alkenes using CsOCF3 as a Trifluoromethoxide Source.
    Author: Chen C, Pflüger PM, Chen P, Liu G.
    Journal: Angew Chem Int Ed Engl; 2019 Feb 18; 58(8):2392-2396. PubMed ID: 30694601.
    Abstract:
    Asymmetric PdII -catalyzed intramolecular aminotrifluoromethoxylation of unactivated alkenes using readily accessible and stable CsOCF3 as a trifluoromethoxide source has been developed, which affords a wide variety of enantiomerically enriched β-substituted OCF3 -containing piperidines in good yields. Introducing a sterically bulky group into pyridine-oxazoline (Pyox) ligands is crucial to increasing both reactivity and enantioselectivity for the reaction. Additionally, the reaction features good functional group compatibility and mild reaction conditions.
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