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  • Title: The Molecular Diagnostics of Vascular Neoplasms.
    Author: Habeeb O, Rubin BP.
    Journal: Surg Pathol Clin; 2019 Mar; 12(1):35-49. PubMed ID: 30709447.
    Abstract:
    In this review, we provide an update of the recently discovered, diagnostically significant genetic aberrations harbored by a subset of vascular neoplasms. From benign (epithelioid hemangioma, spindle cell hemangioma), to intermediate (pseudomyogenic hemangioendothelioma), to malignant (epithelioid hemangioendothelioma, angiosarcoma), each neoplasm features a mutation or gene fusion that facilitates its diagnosis by immunohistochemistry and/or molecular ancillary testing. The identification of these genetic anomalies not only assists with the objective classification and diagnosis of these neoplasms, but also serves to help recognize potential therapeutic targets.
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