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  • Title: [Duodenal ulcer therapy with cimetidine. A clinical endoscopic study in 76 patients (author's transl)].
    Author: Dobrilla G, Valentini M, Filippini M, Felder M, Bonoldi MC, Moroder E.
    Journal: MMW Munch Med Wochenschr; 1978 Jun 16; 120(24):839-42. PubMed ID: 307155.
    Abstract:
    34 patients were treated with cimetidine and placebo in a double blind trial and 42 were treated with cimetidine alone. Criteria investigated were the pain response, consumption of antacids when required and especially the endoscopically demonstrated scarring of the duodenal ulcer. Compared with placebo, cimetidine is capable of soothing pain and also reducing the consumption of antacids more quickly and to a greater extent. The differences are statistically significant. Complete anatomical healing of the ulcer was established in the double blind study in 80% of the patients in the cimetidine group and in 40% of the placebo group. Similar results were also shown in the group which received cimetidine alone.
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