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  • Title: Effects of 2-methylthio ATP on insulin secretion in the dog in vivo.
    Author: Ribes G, Bertrand G, Petit P, Loubatières-Mariani MM.
    Journal: Eur J Pharmacol; 1988 Oct 11; 155(1-2):171-4. PubMed ID: 3072210.
    Abstract:
    The effects of 2-methylthio ATP, an ATP analogue that is more specific for the P2Y receptor, were investigated on insulin secretion in the anesthetized dog in vivo. 2-Methylthio ATP was infused directly into the pancreaticoduodenal artery for 15 min. The infusion was performed so as to obtain a pancreaticoduodenal artery blood level of about 15 microM. 2-Methylthio ATP induced an immediate and significant stimulation of insulin secretion measured from the pancreaticoduodenal vein by means of a T-shaped catheter. After the infusion was stopped, the secretion of insulin progressively decreased and at 30 min was close to basal values. The stimulation of insulin secretion induced a transient but significant reduction of peripheral venous blood glucose levels.
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