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Title: Cytorhizins A-D, Four Highly Structure-Combined Benzophenones from the Endophytic Fungus Cytospora rhizophorae. Author: Liu H, Tan H, Chen Y, Guo X, Wang W, Guo H, Liu Z, Zhang W. Journal: Org Lett; 2019 Feb 15; 21(4):1063-1067. PubMed ID: 30726094. Abstract: Cytorhizins A-D, four novel polyketide heterodimers, were isolated from the endophytic fungus Cytospora rhizophorae A761. These new compounds shared an unprecedented 6/6/5/6/8 or 6/6/5/6/7 pentacyclic ring system and fused as a fascinating cagelike skeleton, embodying by a polyoxygenated isopentyl unit and a highly structure-combined benzophenone scaffold. Their structures were elucidated by extensive spectroscopic analyses and X-ray diffraction techniques. Moreover, compounds 1-4 were evaluated for in vitro cytotoxicity and antimicrobial activity.[Abstract] [Full Text] [Related] [New Search]