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  • Title: Treatment of children with chronic hepatitis B with a combination of steroids and human lymphoblastoid interferon.
    Author: Giacchino R, Facco F, Giambartolomei G, Navone C, Timitilli A, Cirillo C, Barigione G, Terragna A.
    Journal: Chemioterapia; 1988 Dec; 7 Suppl 3():20-5. PubMed ID: 3073870.
    Abstract:
    The efficacy of human lymphoblastoid interferon (Wellferon) therapy was measured in 20 children with chronic hepatitis B with or without pretreatment with prednisolone. Patients were randomised to receive 0.6 mg/kg/day prednisolone for 3 weeks, then at 0.3 mg/kg for a fourth week or placebo. All patients then received interferon 5 MU/m2 i.m. for 12 weeks; daily for 5 days then three times a week for the remaining 11 weeks. Preliminary results show that 25% of children had a permanent loss of viral markers of replication. However, response to interferon varied widely between individuals and a prolonged follow-up is required in order to determine the influence of prednisolone pretreatment on the efficacy of interferon therapy.
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