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  • Title: Comparative effect of captopril and nifedipine in normotensive patients with incipient diabetic nephropathy.
    Author: Insua A, Ribstein J, Mimran A.
    Journal: Postgrad Med J; 1988; 64 Suppl 3():59-62; discussion 90-2. PubMed ID: 3074298.
    Abstract:
    The effect of a six-week treatment by placebo, the calcium channel blocker nifedipine or the converting enzyme inhibitor captopril was assessed in normotensive patients with insulin-dependent diabetes and incipient nephropathy. In response to captopril and nifedipine, arterial pressure decreased slightly and to a similar extent. These drugs resulted in opposite effects on urinary albumin excretion (increase in urinary albumin excretion by 40% during nifedipine and decrease by 40% during captopril treatment). No change in urinary albumin excretion was observed in the placebo group. This observation of opposite changes in urinary albumin excretion in the presence of a similar fall in arterial pressure suggests that the effect of captopril and nifedipine on urinary albumin excretion results from some difference in their intrarenal action.
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