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  • Title: Use of saliva lithium determinations for monitoring lithium therapy.
    Author: Preskorn SH, Abernethy DR, McKnelly WV.
    Journal: J Clin Psychiatry; 1978 Oct; 39(10):756-8. PubMed ID: 30760.
    Abstract:
    During acute and chronic administrations of lithium, 25 patients were studied to determine the effect of other psychotropic drugs on the plasma-saliva lithium concentration correlations. Changes, even discontinuation, in either tricyclic antidepressants or neuroleptics did not affect the plasma-saliva ratio which had an overall correlation coefficient of r = 0.79 (p less than 0.01). The relationship using linear regression analysis was described by the equation, y = 2.27x--0.45. Individual patients' plasma-salivary relations were described by this equation in 87% of cases. The study extends the usefulness of these determinations to include patients on lithium and neuroleptics or tricyclic antidepressants.
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