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  • Title: Caliber-targeted reinterventional overdilation of iliac vein Wallstents.
    Author: Raju S, Knight A, Buck W, May C, Jayaraj A.
    Journal: J Vasc Surg Venous Lymphat Disord; 2019 Mar; 7(2):184-194. PubMed ID: 30771830.
    Abstract:
    BACKGROUND: Wallstents (Boston Scientific, Marlborough, Mass) are most commonly used in iliac-caval stenting. Approximately 20% of stented limbs require reintervention to correct in-stent restenosis (ISR) or stent compression (SC). Corrective balloon dilation to rated stent caliber (isodilation) is not always successful. We investigated whether modest overdilation of the Wallstent by 2 to 4 mm (10%-20%) beyond the rated diameter would yield better mechanical clearance of ISR/SC, leading to a larger flow channel, improved conductance, reduction of peripheral venous pressure, and better clinical outcome. Outflow lumen caliber exponentially influences peripheral venous pressure, a key mechanism in chronic venous disease. Beyond the mechanical effects, the rationale for overdilation rests on the theory that an improvement in flow channel at the margins may yield an outsized pressure reduction and clinical improvement. METHODS: There were 274 previously stented limbs that underwent reinterventional balloon dilation for clearance of ISR/SC during a recent 3-year period. Isodilation to rated diameter of the stent was judged effective in 71 limbs (isodilated subset); 203 limbs (overdilated subset) for which initial isodilation was ineffective underwent overdilation of the resident Wallstent by 2 to 4 mm (10%-20%) beyond the original rated diameter. IVUS planimetry was used intraoperatively to calculate SC and ISR and their subsequent clearance in the two subsets. The dilated segments were observed by clinical and duplex ultrasound examination afterward. The two subsets were compared in the following outcome measures: intraprocedural efficacy in clearing ISR/SC and achieving target lumen caliber, subsequent clinical outcomes, duplex ultrasound caliber durability, and improvement in supine foot venous pressures. This is a single-center retrospective analysis of data contemporaneously entered into a time stamped electronic medical record system. RESULTS: The median follow-up was 18 months (range, 1-35 months). Overdilation of the stent resulted in significantly better intraoperative flow channel area improvement per intravascular ultrasound. This was reflected in significantly better clinical outcome and improvement in peripheral venous pressure in the overdilated subset. Overdilation appeared to be durable up to 20 months after intervention by duplex ultrasound monitoring. CONCLUSIONS: Overdilation appears to be a useful technique to correct ISR/SC and to restore target lumen caliber during reinterventional correction of a resident iliac vein Wallstent. More durable caliber improvement, superior clinical outcome, and reduction in peripheral venous hypertension were noticed in overdilated stents compared with isodilation.
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