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  • Title: Briarenones A‒C, New Briarellin Diterpenoids from the Gorgonian Briareum violaceum.
    Author: Cheng Y, Ahmed AF, Orfali RS, Dai CF, Sheu JH.
    Journal: Mar Drugs; 2019 Feb 17; 17(2):. PubMed ID: 30781569.
    Abstract:
    Three new eunicellin-derived diterpenoids of briarellin type, briarenones A‒C (1‒3), were isolated from a Formosan gorgonian Briareum violaceum. The chemical structures of the compounds were elucidated on the basis of extensive spectroscopic analyses, including two-dimensional (2D) NMR. The absolute configuration of 1 was further confirmed by a single crystal X-ray diffraction analysis. The in vitro cytotoxic and anti-inflammatory potentialities of the isolated metabolites were tested against the growth of a limited panel of cancer cell lines and against the production of superoxide anions and elastase release in N-formyl-methionyl-leucyl-phenyl-alanine and cytochalasin B (fMLF/CB)-stimulated human neutrophils, respectively.
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