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Title: [Coagulation function and hemorrhagic diseases in preterm infants with different gestational ages].
Author: Gao L, Lin XZ, Wu QQ, Lin YC, Hong KY.
Journal: Zhongguo Dang Dai Er Ke Za Zhi; 2019 Feb; 21(2):120-124. PubMed ID: 30782272.
Abstract:
OBJECTIVE: To study the correlation between coagulation function and gestational age in preterm infants and the possible value of coagulation function measurement in predicting hemorrhagic diseases. METHODS: The clinical data of preterm infants who were hospitalized between September 2016 and August 2017 were collected. The coagulation indicators were measured within 2 hours after birth. According to the gestational age, the preterm infants were divided into late preterm infant group (n=322), early preterm infant group (n=241) and extremely/very early preterm infant group (n=128). Coagulation function was compared among the three groups, as well as between the preterm infants with and without hemorrhagic diseases within 3 days after birth. RESULTS: There were significant differences in thrombin time (TT), prothrombin time (PT), activated partial thromboplastin time (APTT), fibrinogen degradation product (FDP) and D-dimer (DD) among the three groups (P<0.05). APTT, PT, FDP and DD were negatively correlated with gestational age, while TT was positively correlated with gestational age (P<0.05). The preterm infants with hemorrhagic diseases had a longer APTT and a higher level of DD (P<0.05). CONCLUSIONS: Coagulation function gradually becomes mature in preterm infants with the increase in gestational age. Abnormal APTT and DD indicate that preterm infants may have a higher risk of hemorrhagic diseases. 目的: 分析早产儿凝血功能与胎龄间的相关性，并探讨凝血功能检测对出血性疾病的可能预测价值。方法: 收集2016年9月至2017年8月住院的早产儿的相关临床资料以及生后2 h内凝血功能检测结果。依据胎龄分为晚期早产儿组（n=322）、早期早产儿组（n=241）和超/极早产儿组（n=128），比较不同胎龄各组早产儿的凝血功能；并比较生后3 d内有无并发出血性疾病早产儿的凝血功能检测指标。结果: 不同胎龄的3组间凝血酶时间（TT）、凝血酶原时间（PT）、活化部分凝血活酶时间（APTT）、纤维蛋白原降解产物（FDP）、D-二聚体（DD）的比较差异有统计学意义（P < 0.05），其中APTT、PT、FDP、DD与胎龄呈负相关，而TT与胎龄呈正相关（P < 0.05）。与未患出血性疾病的早产儿相比，罹患出血性疾病早产儿的APTT延长（P < 0.05），DD值升高（P < 0.05）。结论: 早产儿随着胎龄的增长，生后凝血功能逐渐成熟。APTT及DD检测结果异常，预示早产儿可能会具有更高的风险罹患出血性疾病。

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