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  • Title: [Effect of highly purified thymus factor on the cellular and humoral indices of immunity in thymectomized mice].
    Author: Belokrylov GA, Morozov VG, Khavinson VKh, Sofronov BN.
    Journal: Biull Eksp Biol Med; 1978; 86(7):51-53. PubMed ID: 307966.
    Abstract:
    Effect of homogeneous polypeptide thymus factor of mol weight about 5000 (thymarin-III) on cellular and humoral immune responses of thymectomized adult CBA mice was studied. Thymectomy proved to greatly decrease the number of T-cells in the spleen. Accordingly, the capability of these mice to produce both IgM and IgG antibody-forming cells in response to the thymus-dependent antigen (sheep red blood cells) was significantly depressed. Subcutaneous injections of thymarin-III (1 microgram per g of body weight) for 7 days completely restored the T-cell spleen population and normalized the animals' immune response.
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