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  • Title: Angioimmunoblastic lymphadenopathy: a T-cell deficiency.
    Author: Kosmidis PA, Axelrod AR, Palacas C, Stahl M.
    Journal: Cancer; 1978 Aug; 42(2):447-52. PubMed ID: 307980.
    Abstract:
    The case of a 49-year-old man with the diagnosis of angioimmunoblastic lymphadenopathy is reported. The patient survived a stormy clinical course. The corticosteroids improved dramatically the clinical picture although the patient developed a staphylococcal septicemia. Before treatment immunological studies were done including quantitation of B and T-cells, antigen stimulation of lymphocytes in vitro, skin tests and skin window. Impairment of cell mediated immunity, decreased T-lymphocytes and increased B-lymphocytes were found. A decreased migration of lymphocytes in the skin window was also found compatible with immunosuppression. A possible presumptive pathogenetic mechanism is described although the cause of this recently described entity remains unknown.
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