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  • Title: Leukemia derived growth factors produced by human malignant T-lymphoid cell lines.
    Author: Uittenbogaart CH, Nishanian PG, Anisman DJ, Erikson TK, Fahey JL.
    Journal: Cancer Res; 1986 Mar; 46(3):1219-23. PubMed ID: 3080240.
    Abstract:
    An autocrine (noninterleukin 2) growth factor, which we term leukemia derived growth factor (LDGF), has previously been found in the culture supernatant of the human malignant T-lymphoid cell line MOLT-4f. We now show that two other human malignant T-lymphoid cell lines, CCRF-CEM and CCRF-HSB-2 also produce such a factor. All three factors, i.e., the LDGF from MOLT-4f, CCRF-CEM, and CCRF-HSB-2 are similar to each other both in biological activity and in physicochemical characteristics. In addition to their autocrine activity, these LDGFs stimulate the growth of other malignant T-lymphoid cell lines, but they do not stimulate B-lymphoblastoid or myeloid cell lines. The results therefore suggest that these LDGFs are T-cell specific.
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