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Title: Congenital stationary night blindness: an animal model. Author: Witzel DA, Smith EL, Wilson RD, Aguirre GD. Journal: Invest Ophthalmol Vis Sci; 1978 Aug; 17(8):788-95. PubMed ID: 308060. Abstract: Electroretinographic studies of myctalopic Appaloosa horses demonstrated photopic and scotopic abnormalities similar to those in humans with congenital stationary night blindness (CSNB) of the Schubert-Bornschein type. The phototopic abnormalities consisted of reduced b-wave amplitudes and slower than normal b-wave implict time. The dark-adapted ERG's consisted of a simple negative potential; the scotopic b-wave was nonrecordable. However, a normal c-wave was present in the dark-adapted response. Histologic studies demonstrated no structural abnormalities that could explain the functional defect.[Abstract] [Full Text] [Related] [New Search]