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  • Title: Tuberculosis--United States, 1985--and the possible impact of human T-lymphotropic virus type III/lymphadenopathy-associated virus infection.
    Author: Centers for Disease Control (CDC).
    Journal: MMWR Morb Mortal Wkly Rep; 1986 Feb 07; 35(5):74-6. PubMed ID: 3080659.
    Abstract:
    Data on the number of reported cases of tuberculosis in the US in 1985 support the hypothesis that human T-lymphotropic virus type III/lymphadenopathy-associated virus (HTLV-III/LAV) infection of persons infected with the tubercle bacillus has caused an increase in tuberculosis in some areas. The 21,801 tuberculosis cases reported in 1985 represented a 2% decline from the 1984 total of 22,255 cases. However, the average decline in the 1982-84 period was 6.7%, indicating a slowing of the downward trend in 1984-85. Some of the areas with the largest increases in tuberculosis morbidity in 1985--New York, Texas, California, and Florida--also reported large numbers of cases of acquired immunodeficiency syndrome (AIDS). Matching of the New York City AIDS and tuberculosis case registers has revealed increasing numbers of AIDS patients with histories of tuberculosis, and growing numbers of intravenous drug abusers have been diagnosed as having tuberculosis. 109 (10%) of the 1094 AIDS patients reported from Florida through the end of 1985 have also been diagnosed with tuberculosis. It has been hypothesized that compromised immunity secondary to HTLV-III/LAV infection may favor activation of pre-existing latent Mycobacterium tuberculosis infection. The better understand this problem and design control strategies, the following must be established: 1) the proportion of tuberculosis patients who also have AIDS, 2) the proportion of specific subpopulations with tuberculosis that have HTLV-III/LAV infection, 3) the proportion of AIDS patients who have had tuberculosis diagnosed, 4) the relative risk among person with both tuberculosis infection and HTLV-III/LAV infection of developing clinical tuberculosis, 5) whether patients with HTLV-III/LAV infection and tuberculosis are more or less likely to transmit tuberculosis infection, 6) the validity of tuberculin skin test results for person with AIDS, and 7) the efficacy of current treatment regimens among patients with HTLV-III/LAV infectiion and tuberculosis.
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