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  • Title: [Induction of tyrosine aminotransferase (EC 2.5.1.5) by nicotinamide in rat liver (author's transl)].
    Author: Kröger H, Grätz R.
    Journal: J Clin Chem Clin Biochem; 1978 Sep; 16(9):525-9. PubMed ID: 30807.
    Abstract:
    In intact rats nicotinamide induces an increase of tyrosine aminotransferase depending on the dose of nicotinamide. In adrenalectomized rats an increase of tyrosine aminotransferase activity is only found up to a dose of 250 mg/kg nicotinamide. The combination of nicotinamide with L-methionine and/or cortisone acetate does not cause a significant increase of the enzyme activity, which, however, can be seen in the presence of L-tyrosine.
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