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  • Title: Detection of alpha-transducin in retinal rods but not cones.
    Author: Grunwald GB, Gierschik P, Nirenberg M, Spiegel A.
    Journal: Science; 1986 Feb 21; 231(4740):856-9. PubMed ID: 3080807.
    Abstract:
    The distribution in chicken retina of the alpha subunit of transducin, the guanine nucleotide--binding protein that couples light-dependent activation of rhodopsin with activation of guanosine 3',5'-monophosphate phosphodiesterase, was determined with the aid of a specific antiserum. alpha-Transducin was found in rod photoreceptor cells but was not detected in cones. These results show that rods and cones differ with respect to alpha-transducin content and suggest that the processes of phototransduction may differ correspondingly in rods and cones.
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